Database : HANSEN Search on : CAMUNDONGOS ENDOGAMICOS C57BL/IMUNOL [Subject descriptor] References found : 10 [refine] Displaying: 1 .. 10   in format [Detailed]

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Id: 13944 Author: Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan Title: Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling ..- Source: s.l; s.n; 2003. 4 p. graf. Abstract: Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU). Descriptors: CELULAS CHO LINHAGEM CELULAR IMUNIDADE NATURAL/genet ARGININA/genet HANSENIASE VIRCHOWIANA/genet HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol GLICOPROTEINAS DE MEMBRANA/defic GLICOPROTEINAS DE MEMBRANA/genet GLICOPROTEINAS DE MEMBRANA/fisiol CAMUNDONGOS ENDOGÂMICOS C57BL CAMUNDONGOS KNOCKOUT MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM TUBERCULOSIS/imunol POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol TRANSDUCAO DE SINAL/imunol TRIPTOFANO/genet RECEPTORES DA SUPERFICIE CELULAR/defic RECEPTORES DA SUPERFICIE CELULAR/genet RECEPTORES DA SUPERFICIE CELULAR/fisiol Limits: HUMANO ANIMAL HAMSTERS CAMUNDONGOS SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09085/s

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Id: 13414 Author: Closs, O; Kronvall, G Title: Experimental murine leprosy ..- Source: s.l; s.n; 1975. 6 p. ilus, tab. Abstract: Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.(AU). Descriptors: MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS ANTICORPOS ANTIBACTERIAS HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOELETROFORESE BIDIMENSIONAL HANSENIASE/imunol CAMUNDONGOS ENDOGÂMICOS C3H/imunol CAMUNDONGOS ENDOGÂMICOS C57BL/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limits: HUMANO ANIMAL FEMININO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00024/s

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Id: 12292 Author: Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi Title: Protective responses against experimental mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates ..- Source: s.l; s.n; Feb. 2001. 5 p. ilus, graf. Descriptors: ANTIGENOS DE BACTÉRIAS VACINA BCG VACINA BCG VACINA BCG SEQUENCIA DE BASES PRIMERS DO DNA HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS Limits: ANIMAL Location: BR191.1; 08623/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 11686 Author: Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi Title: Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates ..- Source: s.l; s.n; 2001. 5 p. ilus, graf. Descriptors: MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM BOVIS MYCOBACTERIUM BOVIS HANSENIASE HANSENIASE ANTIGENOS DE BACTÉRIAS VACINA BCG VACINA BCG VACINA BCG SEQUENCIA DE BASES PRIMERS DO DNA CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL PLASMIDEOS BAÇO Limits: ANIMAL MASCULINO CAMUNDONGOS Location: BR191.1; 08478/s

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Id: 10379 Author: Singh, N; Birdi, T. J; Antia, N. H Title: Nerve growth factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. leprae infection and macrophage secretory products ..- Source: s.l; s.n; 1997. 9 p. ilus, tab, graf. Descriptors: ELISA FIBROBLASTOS HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL PROTEINAS ONCOGENICAS V-FOS CÉLULAS DE SCHWANN Fatores de Crescimento Neural/*ME Limits: ANIMAL Location: BR191.1; 07507/s

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Id: 10270 Author: Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H Title: Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6 ..- Source: s.l; s.n; 1998. 10 p. tab, graf. Descriptors: DIVISAO CELULAR COCULTURA HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07165/s

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Id: 10105 Author: Moura, A. C. N; Modolell, M; Mariano, M Title: Down-regulatory effect of Mycobacterium leprae cell wall lipids on phagocytosis, oxidative respiratory burst and tumour cell killing by mouse bone marrow derived macrophages ..- Source: s.l; s.n; 1997. 6 p. ilus, tab, graf. Descriptors: PAREDE CELULAR DEPRESSAO QUIMICA HANSENIASE LIPIDIOS LIPIDIOS LIPOSSOMOS ATIVAÇAO DE MACROFAGOS MACROFAGOS MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE FAGOCITOSE EXPLOSAO RESPIRATORIA SUPEROXIDOS CELULAS DA MEDULA OSSEA/*DE/PH CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07046/s

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Id: 10005 Author: Peake, P. W; Britton, W. J; Davenport, M. P; Roche, P. W; McKenzie, K. R Title: Analysis of B-cell epitopes in the variable C-terminal region of the mycobacterium leprae 70-kilodalton heat shock protein ..- Source: s.l; s.n; 1993. 7 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTICORPOS MONOCLONAIS FORMAÇAO DE ANTICORPOS LINFOCITOS B ELISA EPITOPOS GENES BACTERIANOS PROTEINAS DO CHOQUE TÉRMICO PROTEINAS DO CHOQUE TÉRMICO HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS ENDOGAMICOS CBA CONFORMAÇAO MOLECULAR DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MAPEAMENTO DE PEPTIDIOS PROTEINAS RECOMBINANTES PROTEINAS RECOMBINANTES Location: BR191.1; 06901/s

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Id: 3763 Author: Turcotte, R; Ishaque, M Title: Impairment of virulence of in vitro subcultures of Mycobacterium lepraemurium ..- Source: s.l; s.n; 1983. 3 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAEMURIUM MICOBACTERIOSE MICOBACTERIOSE TÉCNICAS BACTERIOLOGICAS MEIOS DE CULTURA CAMUNDONGOS ENDOGAMICOS C3H CAMUNDONGOS ENDOGAMICOS C57BL ESPECIFICIDADE DE ESPÉCIES VIRULENCIA Location: BR191.1; 02602/s

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